Product name: Indole-3-carbinol
Appreance: White fine powder
Chemical name: Indolemethanol; Indole-3-carbinol;
3-(Hydroxymethyl)indole; 3-Indolemethanol; 1H-Indol-3-ylmethanol;
Molecular formula :C9H9NO
Purity: ≥ 99% by HPLC
Loss on drying≤0.5%
Use : Nutraceuticals, or intermediate for medicines
Package : 25kg per paper barrel
Storage : Refrigerate (+4°C). Protect from light
2.Indole 3 methanol 3-Hydroxymethylindole
Residue on ignition
Loss on drying
Total plate count
Indole 3 Carbinol is a type of Indole. Chemically, it is a
metabolite of Glucobrassicin, which in turn is a hydrolytic product
Indole-3-carbinol and its main metabolite diindoylmethane modulates
several nuclear transcription factors resulting in a variety of
biological and biochemical effects. Indole-3-carbinol works as a
strong antioxidant, thereby protecting the DNA and other cell structures.
Indole-3-carbinol has chemopreventive activity and stimulates the production of detoxifying enzymes. The
phytochemical protects against carcinogenic effect of pesticides
and other toxins.
The anticancer effects of indole-3-carbinol and its metabolite diindoylmethane
are the result of specific activities: inducing enzymes that
metabolize carcinogens, enhancing DNA repair, inducing G1 cell
cycle arrest and apoptosis. Indole-3-carbinol blocks estrogen
receptor sites on the membranes of breast and other cells, thereby
reducing the risk of cervical and breast cancer. Indole-3-carbinol increases the ratio of 2-hydroxyestrone to 16
alpha-hydroxyestrone and inhibits the 4-hydroxylation of estradiol.
This is a favourable action of indole-3-carbinol because 16
alpha-hydroxyestrone and 4-hydroxyestrone have carcinogenic action.
The estrogen metabolite 2-hydroxyestrone has protective against
several types of cancer. Studies with animals have demonstrated
that indole-3-carbinol reduced the carcinogenic affects of
aflatoxins. The influence of indole-3-carbinol on the development
of prostate cancer is less clear. Most studies report protective effects but a few
studies indicate that indole-3-carbinol may promote prostate cancer
formation. Treatment of skin cancer cells with ultraviolet-B results in the apoptosis of their
apoptosis, a favorable effect that seems to be stimulated by
indole-3-carbinol. Some studies also show a beneficial effect on
the treatment of skin cancer.
A few studies demonstrate the beneficial effects of
indole-3-carbinol on lipid synthesis and platelet aggregation,
suggesting that this phytochemical could help to improve heart health.