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supplying Indole-3-carbinol powder, with high purity 99% by HPLC

XI'AN NATURAL -FIELD BIO-TECHQUE CO.,LTD

supplying Indole-3-carbinol powder, with high purity 99% by HPLC

Place of Origin : China

Brand Name : NF

Certification : ISO BV HACCP

Packaging Details : 1kg/bag in aluminium foil bag or as your requirement

Delivery Time : in stock

Payment Terms : T/T in advance, paypal , escrow, western union

Supply Ability : 200kg per month

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1.Basic information:

Product name: Indole-3-carbinol

Appreance: White fine powder

Chemical name: Indolemethanol; Indole-3-carbinol; 3-(Hydroxymethyl)indole; 3-Indolemethanol; 1H-Indol-3-ylmethanol; Indole-3-methanol; 1H-Indole-3-methanol

CAS No.:700-06-1

EINECS No.:211-836-2

Molecular formula :C9H9NO

Molecular weight:147.18

Purity: ≥ 99% by HPLC

Melting Point(mp):96-99°C

Loss on drying≤0.5%

Use : Nutraceuticals, or intermediate for medicines
Package : 25kg per paper barrel
Storage : Refrigerate (+4°C). Protect from light


2.Indole 3 methanol 3-Hydroxymethylindole

Content

Specification

Results

Assay(HPLC)

≥99.0%

99.4%

Melting range

96.0-100.0

97.2-98.7

Residue on ignition

0.1%

0.04%

PH

5-8

6-7

Loss on drying

1.0%

0.46%

Pb

5ppm

Conforms

Arsenic

1ppm

Conforms

Total plate count

500cuf/g

Conforms

Moulds

100cuf/g

Conforms

E .coli

Negative

Negative

Salmonella

Negative

Negative


3. Description
Indole 3 Carbinol is a type of Indole. Chemically, it is a metabolite of Glucobrassicin, which in turn is a hydrolytic product of Glucosinolates.


4.Function:

Indole-3-carbinol and its main metabolite diindoylmethane modulates several nuclear transcription factors resulting in a variety of biological and biochemical effects. Indole-3-carbinol works as a strong antioxidant, thereby protecting the DNA and other cell structures.

Chemopreventive

Indole-3-carbinol has chemopreventive activity and stimulates the production of detoxifying enzymes. The phytochemical protects against carcinogenic effect of pesticides and other toxins.

Anticancer

The anticancer effects of indole-3-carbinol and its metabolite diindoylmethane are the result of specific activities: inducing enzymes that metabolize carcinogens, enhancing DNA repair, inducing G1 cell cycle arrest and apoptosis. Indole-3-carbinol blocks estrogen receptor sites on the membranes of breast and other cells, thereby reducing the risk of cervical and breast cancer. Indole-3-carbinol increases the ratio of 2-hydroxyestrone to 16 alpha-hydroxyestrone and inhibits the 4-hydroxylation of estradiol. This is a favourable action of indole-3-carbinol because 16 alpha-hydroxyestrone and 4-hydroxyestrone have carcinogenic action. The estrogen metabolite 2-hydroxyestrone has protective against several types of cancer. Studies with animals have demonstrated that indole-3-carbinol reduced the carcinogenic affects of aflatoxins. The influence of indole-3-carbinol on the development of prostate cancer is less clear. Most studies report protective effects but a few studies indicate that indole-3-carbinol may promote prostate cancer formation. Treatment of skin cancer cells with ultraviolet-B results in the apoptosis of their apoptosis, a favorable effect that seems to be stimulated by indole-3-carbinol. Some studies also show a beneficial effect on the treatment of skin cancer.


Heart health

A few studies demonstrate the beneficial effects of indole-3-carbinol on lipid synthesis and platelet aggregation, suggesting that this phytochemical could help to improve heart health.


China supplying Indole-3-carbinol powder, with high purity 99% by HPLC factory

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